Thanks for providing more details. It's pretty easy to do some hand calculations of heat loss and compare that to the heat transfer charts in TRNSYS. I did both a TRNSYS model and hand calcs for my own well insulated house (15 cm polyiso insulation) and the results were nearly identical.
The other area to explore is the basement or slab surface of the model. Is the heat transfer there reasonable? You could temporarily delete or disable the slab surface in the model to make sure the above ground surfaces are acting appropriately. Also, double check that the infiltration values are appropriate.